Endocrine Abstracts

Aims: We aimed to investigate IGF1 and IGFBP3 gene polymorphisms in patients with acromegaly.Methods: We included 34 patients with acromegaly and 37 healthy subjects to study. At baseline examinations, antropometric measurements were done. Genomic DNA from the patients and controls were prepared. Serum, glucose, insulin, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, GH, IGF1 and IGFBP3 levels of subjects were analyzed.<p class="a...

Background: Acromegaly is associated with increased morbidity and mortality from cardiovascular disease. Hypertension is a number of common cardiovascular risk factors in acromegalic patients. The aim of this study was to investigate association between the frequencies of angiotensin converting enzyme (ACE) I/D and angiotensinogen (AGT) M235T polymorphisms, the genes belongs to the renin–angiotensin–aldosterone system, and clinical parameters of acromegaly patients.<...

Objective: Insulin like growth factors (IGFs) are important regulators of pancreatic β cell devolopment, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF- 1 gene polymorphism in obese patients with insulin resistance.Methods: We included 100 obese pati...